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Welcome to the Center for Computer Integrated Systems for Microscopy and Manipulation (CISMM) at UNC Chapel Hill, funded by the National Institutes of Health and National Institute of Biomedical Imaging and Bioengineering through award number 5-P41-EB002025.  CISMM develops force technologies applicable over a wide range of biological settings. From the single molecule to the tissue; applied to cancer, thromboses and lung disease, these integrated systems orchestrate facile instrument control, multimodal imaging and unique high throughput microscopy instrumentation.  Complementing this tool set is the development of a wide range of analysis and visualization tools, in the desktop and in virtual environments, that are being applied to domains from the molecular models of cellular structure, to flows in the three dimensional mesh of blood clots, to a dynamic atlas of geometry and growth in pediatric airways.

Latest News

Volume scan of a fixed HeLa Cell expressing vimentin-mEmerald (blue) and stained with Phallodin (red) highlights the internal structure of vimentin and resolves individual filopodia on the cell surface. Cells were a courteous gift from the Boyce Lab at Duke University.
Fast volumetric imaging (0.75 s/volume) of a RAW macrophage stably expressing HaloTag-F-Tractin labeled with Janelia Fluor 549 shows single-second timescale filopodia dynamics.

Technology Research and Development (TRD)

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TRD 1: Force Microscope Technologies
TRD 2: Molecular Imaging Tools

Collaborations form the heart of our resource

Their influence has grown to 18 collaboration projects involving over 28 senior investigator collaborators, with fully one half (9) of the projects located outside of UNC. Collaborators are organized as Collaboration Clusters:

Cell Mechanics Cluster
Lung Cluster
Thrombosis Cluster

Service, Training, and Dissemination

This Resource prides itself on building computer-based tools for microscopy and force measurements to serve the needs of scientists working on the frontiers of knowledge. Our goals are to support visiting scientists, to support Resource-developed hardware/software systems delivered outside the Resource, to support and enhance the research of users who come to our laboratories at UNC.
Service: Come use our resources, either by visiting us at UNC, getting our hardware, or through our free software.
Dissemination: download our software, learn about our work through our publications.
Training: Come learn about forces in biology through our annual Carolina Workshop on Forces in Biology hosted at UNC May 11-13.

Come Use Our Facilities

As an NIH National Research Resource we provide access to our unique facilities to researchers doing related work. Click here to learn more about using this facility.